Historically, heartworm disease has been effectively prevented in dogs by using available preventives. However, recent research indicates that some field isolates and laboratory strains of
Dirofilaria immitis may not be fully susceptible to preventive medications.
1-3 The number of heartworm positive dogs has increased in certain areas of the central United States, namely the Mississippi Valley and Delta regions, despite compliant use of preventives. And other variables, such as testing strategy changes and increased mosquito vectors, have been ruled out as potential explanations. The concern is that a subpopulation of heartworms in these areas has developed resistance to heartworm preventive medications.
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